Comparison of sensitivity of elisa for diagnosing single versus multiple ring lesion in neurocysticercosis in a tertiary care hospital in aligarh

Objectives: 1.To determine the sensitivity of IgG ELISA for diagnosing single lesion neurocysticercosis (NCC) in patients presenting with signs and symptoms of NCC.2.To determine the sensitivity of IgG ELISA for diagnosing multiple lesion NCC in patients presenting with signs and symptoms of NCC.3.To compare sensitivity of ELISA in single vs multiple lesion NCC.
Material and methods: The study was conducted in the Department of Microbiology and allied departments of JNMCH, Aligarh from January 2012 to June 2013. Study group comprised of 45 patients presenting with symptoms suggestive of NCC and were found to have single or multiple ring lesions on MRI. 15 controls were also included in the study. NovaTecTaeniasolium IgG ELISA was used to detect antibodies against Taeniasolium.
Results: Majority of patients 31 (68.9%) were males and the remaining 14 (31.1%) were females. Majority 42 (93.3%) of the patients were found to have a single ring lesion on MRI while only 3 (6.7%) patients had multiple lesions involving more than one lobe. Sensitivity of ELISA was found to be 7.1 % in single lesion compared to 100 % in multiple lesion NCC.
Conclusion: single lesion NCC is more common compared to multiple lesion.Young males form the most common risk group. From the current study it is evident that the sensitivity of ELISA for diagnosing multiple lesion NCC is more (100%) as compared to 7.1 % in single lesion NCC.