A group of complications which representing as a syndrome are interlinked to one another progressing in a sequential manner is known as combination syndrome by Ellsworth Kelly in 1972.It commonly occurs in patients with a completely edentulous maxilla opposed by a bilateral distal-extension removable partial denture. This syndrome poses a considerable challenge to dentists. The symptoms of the syndrome consist of anterior maxillary bone loss, mandibular bone loss, tuberosity overgrowth, and alveolar ridge canting. All of these effects render prosthetic treatment more difficult, and although it is preferable to use dental implants for functional support, complex cases still require conventional prosthetic treatments for medical or financial reasons. This clinical report presents the prosthodontic management of a patient exhibiting a condition that can proceed to combination syndrome, using soft denture lining material and modified impression technique along with a discussion of relevant literature.