Evaluation of the effect of submucosal injection of dexamethasone to control postoperative sequelae after thir dmolar surgery: a prospective, randomized, crossover clinical study

Author: 
Neel Kamal., Vaz Ashwin Alwyn., Alfisha Sheikh., Navneet Kaur and Amit Sharma

Introduction: Impacted third molar surgery is one of the most common procedures per formed by maxillofacial surgeons. Removal of symptomatic or diseased third molars has been shown to improve oral health and function of patients. Corticosteroids extensively used in dentoalveolar surgery are Dexamethasone owing to their nearly pure glucocorticoid effects. Objective: To evaluate the postoperative sequelae like pain, swelling and mouth-opening following the Dexamethasone administration. Materials and method: This study was conducted on 25 patients (50 impacted teeth-split-arches); 8mg Dexamethasone injected intraoral submucosally on one side & other side was injected with Normal-saline injection for placebo effect. Mouth-opening and facial-swelling were evaluated at 2nd and 7th postoperative day. The subjects were asked to enter their pain level using VAS (visual analog scale) rating. The effects on patients were studied using parameters like pain, trismus and swelling. Results: Sample comprising both groups were clinically analysed for pain, swelling and trismus using VAS (visual analog scale) for pain, modification of tape measuring method for swelling, and inter incisal opening for trismus. Conclusion: Statistically significant difference noted between two groups with respect to pain, swelling and trismus. Clinically patients on Dexamethasone had better relief with regards to pain, trismus and swelling when compared to Normal-saline group. This study shows that submucosal Dexamethasone successfully reduces the post-operative sequelae after third molar surgery. Hence, 8mg Dexamethasone can be used in routine third molar surgery to improve the postoperative quality of life of the patient.

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