WHO estimated that 21.4 lakh TB cases notified in India in 2021,. India’s TB incidence for the year 2021 is 210 per 100,000 population compared to the baseline year 2015, there has been an 18% decline which is 7 % points better than the global average of 11%. Worldwide, TB is the 13th leading cause of death and the second leading infectious killer after COVID-19. In 2022, an estimated 10.6 million people fell ill with tuberculosis (TB) worldwide, including 5.8 million men, 3.5 million women and 1.3 million children. But TB is curable and preventable. It estimated 75 million lives were saved through TB diagnosis and treatment between 2000 and 2021. The present study Title: “A study to assess the effectiveness of Structured Teaching Programme on knowledge regarding the prevention and control of Pulmonary Tuberculosis among adults at selected area of urban community, Guwahati, Assam.” Objectives: To assess the knowledge on prevention and control on Pulmonary Tuberculosis, To evaluate the effectiveness of Structured Teaching Programme on prevention and control on Pulmonary Tuberculosis, To find out the association between pre- test level of knowledge with selected Socio-demographic variables. Conceptual framework: The study was based on general system model of “Ludwig Von Bertalanffy (1968)”.Approach: Quantitative approach was adopted for this study. Design: Pre- experimental one group pre-test post-test design was taken for the study. Setting: The study was conducted at selected area of urban community, Odalbakra, Guwahati. Sample: The sample size was 60 adults. Sampling Technique: Non-probability purposive sampling technique was used. Methods of data collection procedure: Data were collected among adults to assess the level of knowledge by using structured knowledge questionnaire. The collected data were tabulated and analyzed by descriptive and inferential statistics. Result: The result shows, there was a significant difference between pre-test and post-test level of knowledge regarding prevention and control of Pulmonary Tuberculosis among adults. The calculated‘t’ value (19.88) was greater than the table value at 0.05 level of significance. Conclusion: The Structured Teaching Programme was effective (p<0.05) to improve the level of knowledge regarding Prevention and control of Pulmonary Tuberculosis among adults.