Introduction: The aim of this study is to compare and evaluate the efficacy of aforementioned drugs and determine a suitable drug for infraumbilical surgeries. Material and method: Our primary objective was to compare the efficacy of Inj. Chloroprocaine (1%) 4ml + Inj Fentanyl 25µg versus Inj. Ropivacaine (0.5%) 4ml + Inj.Fentanyl 25µg for spinal anaesthesia by using onset, total duration of sensory and motor block.Secondary objectives were to compare effective maintenance of hemodynamic parameters, occurrence of side effects & complications if any Patients were randomly allocated to one of the group Group C Inj. Chloroprocaine (1%, preservative free) 4ml + Inj. fentanyl 25µg and Group R: Inj. Ropivacaine (0.5%, preservative free) 4ml + Inj. fentanyl 25µg using computer generated list with 50 in each group. Statistical analysis: Mean duration of onset of sensory action was 2±1.33 min with Group C, while it was 7.5±2.643 min with Group R (p<0.001). Mean duration of onset of motor action was 1.8 ±1.6856 min with group C, while it was 11.6 ± 2.688 min with group R. Mean duration of maximum motor block was 91.4±10.587 minutes with Group C while it was 144.2±9.99 minutes with Group R. Regression of sensory block required 107.6±10.409 minutes and 207.8±12.512 minutes with group C and group R respectively. Drop in mean arterial pressure, systolic blood pressure and diastolic blood pressure was significantly more in Group R as compared to Group C from baseline (0 minute) level till 140 minutes. Conclusion: In a study of comparison of Chloroprocaine 1% (without preservative) and Ropivacaine 0.5% for intrathecal administration under spinal anaesthesia lasting for 80 to 100 minutes showed that with overall stability , quicker onset and shorter duration of action, Chloroprocaine 1% recommended for intrathecal use in dose of 4ml with Fentanyl 25µg as an additive for short surgical procedures of infraumbilical surgeries.
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2022: 6.012
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