The treatment of cancers with immune checkpoint blockers has been an important revolution in the area of cancer immunology. Advance medication strategy with the implementation of checkpoints blockers predicted that immunologists will deal with new challenges to control the adverse side effects related with the use of these drugs. They also accredit the require for taking a comprehensive reach to the patient, which is a principle broadly acknowledged in oncology and mainly specific in the trial of the extending use of immune checkpoint inhibitors, which can give increase to a broad variety of organ issues arising from treatment. Understanding and attention of the spectrum of immune-related adverse events will permit immunologists to select patients for medication more sophisticated, prevent problems, truth-worthy detected, and finally treat them. There is a crucial requirement for interdisciplinary collaboration in the cancer treatment undergoing immunotherapy and experiencing the subsequent adverse reactions to treatment.