Melasma is an acquired hyperpigmentation disorder of the skin characterised by hyperpigmented macules over face. Aims: To compare the efficacy and safety of intradermal tranexamic acid injections versus autologous platelet rich plasma in patient with melasma. Setting and Design: A hospital based single blinded interventional prospective study. Material and Methods: The patients were randomly assigned into 2 groups consisting of 63 patients each. In group A (54 female and 9 male patients ) were treated with intradermal tranexamic acid injections (4mg/ml) whereas in group B (55 females and 8 male patients ) patients were treated with autologous platelet rich plasma injections .The procedure was repeated after a gap of 2 weeks and a total of 4 sessions were carried out. Assessment was done using the mMASI (modified melasma area and severity index) score. Statistical Analysis: Data was compiled, tabulated and analysed using the SPSS software version 25.0 Results: In group A the mMASI score reduced from 7.73±1.81 to 4.97±1.58 and in group B it reduced from 7.59±1.68 to 3.89±1.36. Side effects were minimal in both groups. Conclusion: Both intradermal tranexamic acid injections and autologous PRP were found to be safe and effective therapeutic options for melasma providing substantial improvement when used as standalone therapies. PRP was found to be better than intradermal tranexamic acid injections.
Impact Factor
2022: 6.012
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