The prescription of labile blood products (LBP) is a crucial step in the transfusion chain. It is subject to numerous insufficiencies which make it a weak link. Our objectives are, on the one hand, to detect and analyze these deficiencies, and on the other hand, to propose measures to reinforce transfusion safety by improving the relevance of the prescriptions of LBP. This work is an observational cross-sectional analytical non-interventional study conducted over 12 months between January and December 2021. It evaluated 5456 LBP orders received at the Blood Transfusion Center of the Mohammed V Military Training Hospital in Rabat. A total of 204 (4%) prescriptions were compliant. Non-compliance was found in all sections of the order, represented mainly by lack of accuracy of biological data (98%), lack of clinical information (95%), and failure to indicate the degree of urgency (93%). No prescription had all seven headings completed and no headings were compliant on 92 prescriptions. Despite the importance of these data, we have established a negative finding concerning their ratio during prescriptions. The control of this worrying result represents a real challenge and requires the implementation of corrective measures refining the act of prescription.