Comorbidity is described as an illness that happens more frequently in connection with a specific condition than would be expected as a coincidental relationship in the general population. Depression, anxiety, stroke, epilepsy, sleep problems, and other pain illnesses are all common comorbidities with migraine. Furthermore, many common disorders occur concurrently (at the same time) with migraine, influencing therapy options (Anzola G. D 1999). When individuals have comorbid or concurrent conditions, migraine therapy, and especially migraine prevention, can be difficult.