Background: PTEN tumor suppressor gene are among most common genomic aberration in prostate cancer. Loss of which leads to activation of P13K-AKT pathway and is strongly associated with increasing gleason grade and adverse oncological outcomes.
Aim: To assess PTEN loss in different gleason grades of prostate carcinoma.
Material and methods: A total of 72 cases of prostatic carcinoma were included in the study. All cases were assessed and categorized into different grade groups. PTEN expression was assessed by immunohistochemistry (IHC) and correlated with Gleason score and grade group.
Results: PTEN expression was assessed in different Gleason score and Grade group. In Gleason score 6 (Grade group I), all the cases were positive for PTEN expression. In Gleason score 7, 75% cases were positive in Grade group II (3+4) and 15% cases were positive in Grade group III (4+3). In Gleason score 8(Grade group IV) and score 9 (Grade group V) 18.75% cases were positive. In Gleason score 10(Grade group V) all cases were negative for PTEN expression.
Conclusion: Assessment of PTEN expression loss may play a significant role in current risk stratification of prostatic carcinoma particularly in low and intermediate risk groups.
Impact Factor
2022: 6.012
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