Background: Oxidative stress has been implicated in cancer development increased level of reactive oxygen species (ROS) that disrupts the intracellular reduction-oxidation (redox) balance. Bone tumors constitute 1% of all tumors and benign are more common than malignant. This study was conducted to measure the levels of oxidant stress and antioxidant mechanism in benign bone tumors before and after surgical intervention.
Methods: 16 patients with biopsy proven benign bone tumors treated at a single centre by a single surgeon were included in this study. 16 healthy controls were also included in the study. Serum Malondialdehyde (MDA) levels were determined to assess oxidative stress while antioxidant status was evaluated using superoxide dismutase (SOD). Two samples were taken – One at the time of diagnosis and another 6 month after surgical intervention.
Results: Patients with benign bone tumors showed significant increase in plasma MDA
Levels (p < 0.05) while significant decreases was noted in SOD levels (p < 0.05). Similarly significant association was found between healthy individuals and patients with benign bone tumors (p < 0.05) in terms of decreased SOD levels and plasma MDA levels.
Conclusions: In conclusion, an increase in oxidative stress and decrease in antioxidant status is observed in bone tumors which is significantly affected after surgical intervention. Further studies on manipulation of redox balance in patients with bone tumors, benign as well as malignant, can act as useful approach in early diagnosis or designing management strategies for bone tumors.
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