Root canal treatment [RCT] is one of the most common dental procedures. Experience of root canal associated pain is a major cause of fear for patients and a very important concern for dentists. Pain control and infection management is the main aim while performing the endodontic therapy. Therefore, analgesics and antibiotics plays a fundamental role of dental procedures as they not only treat the dental infections but also provide pain free procedures. This article provides treatment strategies based on the current scientific evidence for pain management.