There are numerous clinical manifestations of sepsis, but the most common are fever or hypothermia, unexplained tachycardia, leukocytosis or leukopenia, thrombocytopenia or coagulopathy, altered blood pressure and altered mental status. we decided to undertake a study to determine clinical profiles of patients admitted with severe sepsis. A total number of 110 cases of sepsis admitted in the medical wards were studied. This prospective study was conducted with the hospital ethics committee approval and informed written consent. The commonest clinical feature among patients was altered blood pressure 84 (88.4%) followed by altered temperature 78 (82.1%), Altered sensorium 77 (81.8%) and breathlessness 77 (81.1%). Oliguria was seen in 60 (63.2%) patients. Tachycardia was seen in 60 (63.2%) patients and tachypnea was present in 52 (54.7%) cases