Auto-immune bullous disorders includes pemphigus vulgaris which may be extremely debilitating and fatal. They need quick and proper management to avoid fatal complications. In Ayurveda , they may be correlated to Visarpaor Visphota according to the symptomatology. Herein we report a 47-year-old male patient diagnosed with Pemhigus vulgaris who failed to respond to Allopathic medicines and was subsequently treated with Ayurvedic medicines and procedures. Gomoothrapana was included along with internal medications. The patient achieved complete remission of symptoms.