Background: Gallstone diseases, is a common problem nowadays, trend towards minimal invasive surgery played a pivotal role in treatment of symptomatic gallstones. Laparoscopic cholecystectomy is the gold standard procedure throughout the world for the treatment of symptomatic cholelithiasis. In laparoscopic cholecystectomy (LC), cystic duct and cystic artery are normally secured with Titanium clips. Intracorporeal ligation is usually superior to extracorporeal knotting. Aim of this study was to evaluate safety and efficacy of clipless laparoscopic cholecystectomy in closure, compared to conventional laparoscopic cholecystectomy using titanium clip. The study compared mean operative time and postoperative complications. Material and methods: This study was conducted at Department of General Surgery, Patna Medical College, Patna during July 2014 to June 2016. A total of 140 patients, 70 patient each group A & B i.e. ligature group and clip group. Results: Maximum patient undergone cholecystectomy belongs to age group 31-40 years 45 i.e. 32.14%, followed by 21-30 years 30 i.e. 21.43%. Mean operative time in both groups that found ligature group A had more operative time than clip group B i.e. 54.87 and 49.32 minutes. Only one case shows Porte site infection in clip group B. Conclusion: During laparoscopic cholecystectomy, silk or clips can be used to ligate the cystic duct or artery effectively and safely. Suture can be used instead of a clip applicator if one is not available. Both procedures should be well-known to the laparoscopic surgeon.