Background: The appendix is a small, tube like organ attached to the large intestine. Appendicitis is the swelling of the appendix. The condition is due to blockage inside the appendix which leads to increased pressure and inflammation. Serum bilirubin levels have been suggested as individual markers for appendicitis and acute appendicitis (AA) perforation (AP). Aim and objectives: To analyse relation between hyperbilirubinemia and acute appendicitis and to see how reliable it is as a diagnostic marker for AA or AP. Material and methods: A prospective observational study was conducted at Department of General Surgery, Patna Medical College, Patna during July 2014 to June 2016 in 156 patients thorough history were taken and clinical examination was done for all patients and findings were recorded on predesigned and pretested Proforma. Results: Age Mean ± Standard deviation was 30.46 ± 9.62 with gender distribution was found that males i.e. 111 (71.15%) were more than female i.e. 45 (28.85%). Total bilirubin mean ± SD were 0.97 ± 0.31 mg/dl, it has difference in AA & AP i.e. 0.89 ± 0.42 & 1.51 ± 0.75 respectively. Hyperbilirubinemia in terms of sensitivity and specificity in AA was found to be 17.14% and 25.00% respectively. Positive Predictive Value, Negative Predictive Value and diagnostic accuracy of increased serum bilirubin in acute pancreatitiswas 2.48%, 73.09% and 24.21%.Similarly for AP it was found to be 81.25% and 83.57% respectively. Also Positive Predictive Value, Negative Predictive Value and diagnostic accuracy were 35.46%, 97.57% and 83.34%. Conclusion: Findings suggests serum bilirubin levels and liverenzyme to be a promising new laboratory marker for diagnosing acute appendicitis with perforation but acute appendicitis still – clinical.
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