Introduction: The SARS- CoV-2 pandemic attack; which began in Hubei province of Wuhan city of China in December 2019; is one of the serious health issues, which has
challenged entire world and this is the largest outbreak since last four decades. Today there is lot of improvement in health science technology as compared to old days; still almost all countries are struggling to overcome this disease. Overall condition is same for developed as well as developing countries. For developed countries, speed of disease contamination, is not allowing settle it, while for developing countries, health infrastructure is big concern. Though the history of corona virus is quiet old, but yet there is no confirmative treatment against it. The world is familiar about corona virus since past; either in the form of severe acute respiratory syndrome corona virus (SARS-CoV); which started at Guangdong province of China in 2002 or Middle East Respiratory Syndrome corona virus infection
(MERS-CoV-1) of Saudi Arabia in 2012. The virus shows continuous genetic reconstructions, with genetic mutations in human body and express as different and newer version as compared to previous corona. This is main reason, why this difficult to tackle the disease. Objective: To understand SARS- CoV-2 better, from past experiences, for
prevention and management of this disease. Concept Designing: Articles collected through various search engine tools such as, Google Scholar, Ebsco host and Pub med, relevant key words inserted to search these articles such as, Corona virus, SARS, MERS and COVID tec. All articles evaluated to be as per PRISMA guidelines. Conclusion: The SARS- CoV-2 is altered version of previous corona virus infections, which affected entire world in respect to physical health, mental health and global economy. This pandemic disease is different from previous corona virus attacks, in respect to rapid family spreads and variations in clinical presentations. There is need of strict policies by governments which are in collaboration with private sectors and public.