Mango (Mangifera indica) is one of the most important fruit trees in the tropics and subtropics of the world. Mango decline is currently one of the main diseases of mango in Burkina Faso. Preliminary studies revealed Lasiodiplodia theobromae associated the disease. This study was focus on research for solutions to mango decline in Burkina Faso. Six synthetic fungicides and three biopesticides were tested in-vitro on the mycelial growth of Lasiodiplodia theobromae. Fungicides, biopesticides, fertilizers and agricultural practices were used individually or in combination as treatments (T1 to T5) for the field trial in four localities.The results revealed antifungal effect of six fungicides and two biopesticides on mycelial growth on L. theobromae. Manga Plus©, Idefix© and Neco© induced 100% efficacy rate on the champigon at C1= 1000ppm. At the same dose, Banko©, Nativo©, Référence©, Azox©, and Proraly © had a mean inhibition rate of mycelial growth greater than 60%. T1 (Nativo© + Manga plus©+ NPK) and T2 (Nativo© +Manga Plus©) significantly reduced the incidence and severity of the disease. However, Plantsain© and Solsain © have been less effective against the disease. Therefore, as part of an integrated management of the disease in Burkina Faso, Neco© could be better predicted because of its biological nature respectful of the environment, the health of producers and consumers.