The outbreak of Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), has thus far killed over 2,94,046 people and infected over 4,248,000 cases in China and elsewhere in the world, resulting in catastrophe for humans. Although dental clinics have been closed during this epidemic, a large number of patients need emergency treatment. Biological features of 2019- nCOV should be updated in time and comprehensively summarized to help execute control measures and make therapeutic decision. It is need of hour to device practical strategies to block virus transmission and provide reference for preventing transmission of 2019-nCOV during dental diagnosis and treatment, including dentist and dental team preparation, waiting area protocol, patient evaluation, personal protective measure for dental health care worker, precautions before, during and after dental treatment. Precaution measures should be implemented for disinfection of clinical setting, management of medical waste and laboratory work protocols.