Human immunodeficiency virus (HIV) is a retrovirus in the Lentivirus group that targets CD41 T cells. HIV infection leads to lots of opportunistic infection which manifest both orally and generally .The treatment of HIV infected patients involves Antiretroviral therapy along with antibiotics for opportunistic infections. This review paper explains about the mechanism of action of ozone against bacteria and virus activity and the effectiveness of subgingival ozone therapy as an adjunct for the treatment of HIV infected patients.