Review: Thyroid hormone plays an important role in body metabolism and thyroid disorders are common metabolic disorders in the general population. Deficiency or excess causes hypothyroidism and hyperthyroidism respectively. Thyroid disorders are known to affect kidney function and purine nucleotide metabolism.
Aim: This study was carried out to assess the impact of thyroid status on uric acid levels.
Methodology: The study was conducted on 100 subjects from Victoria Hospital and Bowring and Lady Curzon Hospital, attached to Bangalore Medical College and Research Institute, Bangalore. Thyroid function tests (T3, T4 and TSH) and serum uric acid levels were assayed in all the subjects. Based on TSH values, subjects were classified as Euthyroid, Hypothyroid and Hyperthyroid.
Results: In hypothyroid patients, T3 and T4 values were significantly lower than control group and TSH values were significantly higher than the control group. In hyperthyroid patients, T3 and T4 values were significantly higher than the control group and TSH values were significantly lower than the control group. The levels of uric acid were significantly higher in both hypothyroid and hyperthyroid patients than the control group (p< 0.01).
Discussion: Our study compared uric acid levels in cases of thyroid disorders and euthyroid subjects and confirmed that thyroid disorders are associated with increased uric acid levels. Our study was in accordance with previous studies and emphasized the fact that thyroid status should be taken into account when evaluating cases of hyperuricemia.
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2022: 6.012
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