The pain in the hand and wrist joint is common in people who overuse that part of the body with work. The majority of patients are women. The causes are: physical injury, carpal tunnel syndrome, sports (tennis, table tennis, gymnastics), computer work, etc. The most common symptoms for palm and wrist injuries are: pain, stiffness, paresis, swelling, limited mobility, and so on. Acupuncture as part of Traditional Chinese Medicine (TCM) is an effective way to treat this type of problem in patients and for most of the cases only one treatment is needed to improve the condition. In the study were included 15 patients, 4 men and 11 women, aged from 27 to 67 years. All patients were treated with acupuncture for hand and wrist pain. Effect from the treatments was achieved in all patients with certain number of treatments. According to this study and generally according to patients who seek a physician to treat this problem, it is women who suffer more from wrist disease than men. Acupuncture as part of TCM as a treatment for this problem represents an effective and completely safe treatment. Acupuncture facilitates the blood flow, Qi flow, and restores the lost energy. The treatment itself improves the general condition of the body. Most patients are cured after only one treatment.