Smile is an indispensible human facial expression that enhances the reward value of an appealing face. For millennia, the smile has been recognised as a powerful communiqué device, offering benefits to both giver and receiver. A sign of compassion, empathy and friendliness, smile can benefit healthcare professionals and their patients as well. It may facilitate a bond of assurance, hope and trust. But beware the fake smile, which is all too easily identified and may do more harm than good. However no one ever explored it as a medicine that what does a humble and a cheerful smile might afford to the health profession. This review explores the literature surrounding smile in healthcare and beyond, conversing the rationale behind being cheerful, from good health to success in life. Hence a literature search from PubMed, Wiley& Sons, Science direct and Indian scientific journals was done to correlate smile and medicine.