Background: Patients with substance use disorder (SUD) experience social discrimination and have poor quality of life due to biopsychosocial nature of these disorders. Aim: The study was aimed to assess quality of life in these patients and compare with healthy controls. Methods: 72 SUD patients were enrolled into the study from Sep 2018 to May 2019 at Regional hospital, Bilaspur. The patients with tobacco abuse were excluded from the study. Quality of life (QOL) was assessed using WHOQOL BREF questionnaire. Statistical analysis was performed using SPSS v21. Results: 66.6% of the patients were abusing opioids followed by alcohol abuse in 19.4% patients, followed by cannabis in 11.1% patients. Two patients were also consuming benzodiazepines. None of the patients were using two or moresubstances. QoL in the patients with substance use disorders was significantly worse. WHOQOL-BREF score was significantly lower in physical health domain 31.0 [19.0, 39.0], psychological domain 25.0 [13.0, 39.5], social relations 44.0 [25.0, 56.0]and environmental domain 31.0 [19.0, 50.0]. Conclusion: SUDs were associated with poor QOL.