Prevalence of dyslipidemia in men with type 2 diabetes mellitus with low testosterone levels

Aims: To study lipid profile and testosterone levels in men with type 2 diabetes mellitus.
Material and Methods: An observational, cross sectional study was performed in 193 male blood samples were analyzed for Fasting plasma glucose, 2 hours post prandial plasma glucose, glycosylated hemoglobin (HbA1c) and lipid profile (Total Cholesterol, Triglycerides, Low density lipoprotein (LDL) and High density lipoprotein (HDL) levels).Serum Testosterone Levels was measured. Total Testosterone Levels and Free Testosterone Levels were measured based on chemilumiscence on Beckman coulter access 2 immunoassay system (time for collection of samples was between 7am to 11am).Statistical analysis was performed using Epi Info2000 and SPS student version 16.0.
Observations: In our study out of 193 patients. The mean fasting blood glucose of the patients was 183.72 ± 64.06 mg/dl. The mean post prandial blood glucose level of the patients was 242.32±104.32 mg/dl. The average total triglyceride, cholesterol, LDL,HDL were 214.35±98.58 mg/dl, 202.81±50.68mg/dl, 132±40.40mg/dl and 36.46±7.43mg/dl. The incidence of hypertriglyceridemia was 53.60% in patients with low total testosterone levels. Hypercholesteremia was 61.36%in patients with low total testosterone levels and 56.81% in patients with low free testosterone levels. Increased level of LDL was reported in 30 patients (66.66%) with low total testosterone levels and 31patients (68.88%)with low free testosterone levels, and reduced HDL was found in 64 (52.03%) in patients with low testosterone levels. Out of 193 patients 67 (34.71%) had low total testosterone levels and 57 (29.53%) had low free testosterone levels and there is significant relationship between low testosterone levels and dyslipidemia.
Conclusion: Type 2 diabetes mellitus is associated with dyslipidemia and low testosterone levels. Those patients with low testosterone levels had elevated Total serum triglyceride, elevated cholesterol and elevated LDL and reduced levels of HDL levels than with normal testosterone indicating that these patients were more prone to get cardiovascular disease.