Morphological and histopathological changes in great saphenous vein and its effect on duration and severity of varicose veins

Chronic venous disorders remain a common problem worldwide. However, despite increasing research into novel endovenous therapies for the treatment of superficial venous disease, the pathogenesis of primary varicose veins remains poorly understood. Various studies have evaluated the correlation of vessel wall changes with duration and severity of varicose veins. We carried out a prospective study to evaluate the morphological and histopathological changes in great saphenous vein and its correlation with duration and severity of disease in varicose veins. The results of our study concluded that morphological and histopathological changes in great saphenous vein plays a significant role in pathogenesis of primary varicose veins. Also, these changes in the Great Saphenous Vein wall could result in the secondary Sapheno-Femoral Junction incompetence in these patients.