Weight of testes and epididymis was found to be increased in R Nase A+ metosartan treated group than compared to control. Qbanding of testes samples treated with metosartan resulted in collapse of chromosome chain formation where as in remaining groups staining of chromatin is not seen when compared with control. Flow cytometric analysis proved that the drug induces profound apoptosis in both testes and sperm samples. Inspite of this, the drug does not affect histology of rat testes. In sperm sample of rats treated with RNase A + Aspirin showed profound apoptosis compared to testes of same group. Sperm count was restored to some extent in long treatment of normal rats treated with drug metosartan but lower than the remaining groups.
Impact Factor
2022: 6.012
This work is licensed under a