Systemic lupus erythematosus (SLE) is an autoimmune disease with a heterogeneous presentation. The association between clinical presentations in SLE and the Human leukocyte antigen (HLA) genes has never been studied on a Moroccan population. The aim of this work was to evaluate the association between Human leukocyte antigen (HLA) genes and clinical features. HLA class II alleles typing was performed by polymerase chain reaction-sequence-specific primers (PCR-SSP) in 74 patients with SLE. The association between the HLA alleles was identified and compared in patients with and without the various clinical presentations included in the American College of Rheumatology (ACR) criteria.
A significant increase of HLA-DRB1*13 allele (p= 0.028) and decrease of HLA-DRB1*15 allele frequency (38.0% vs. 100.0%) were observed in SLE patients with serositis and arthritis respectively. A significant increase of the HLA-DQB1*04 allele (p = 0.003) were observed in SLE patients with oral ulcers.
The Moroccan population showed protective and predispositional alleles of HLA class II with clinical presentations in SLE patients.
Impact Factor
2022: 6.012
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