Background: Pancytopenia refers to a reduction in all three formed elements of the blood erythrocytes, leukocytes and platelets. Though It is not a disease entity, pancytopenia is a serious hematological problem. Many disease conditions can manifest as pancytopenia. The underlying cause of pancytopenia is diagnosed by bone marrow aspiration and biopsy.
Material & Method: A cross sectional study was done in the Department of Medicine, in a Tertiary care centre in central part of Kerala during a period of one year (1/1/2013 to 1/1/2014). 51 cases of pancytopenia patients admitted in the medicine department were studied. Clinical history, clinical examination, haematological investigations were analysed to make diagnosis. Study was approved by institutional ethical committee.
Results: Mean age at presentation was 50.2 yrs. 68% had fever as presenting complaint. 39.25 had hepatomegaly and 35% had splenomegaly.35.3% had macrocytic anemia in peripheral smear. 31.4% showed megaloblastic change in bone marrow. 25.4% had megaloblastic anemia.
Conclusion: Most common cause for pancytopenia was Megaloblastic anemia. It was prevalent in 51 – 70yrs age group.
Impact Factor
2022: 6.012
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