Chronic inflammatory condition leading to the development of diseases like diabetes type II, Alzheimer's, rheumatoid arthritis, cardiovascular, peripheral arterial disease and others have driven investigators to find pro and anti-inflammatory role of various elements in the human body. Considering the vital role of the essential fatty acids in the functioning of the cell membrane, the authors took up the meta-analysis to determine if omega-6 essential fatty acid is associated with increase in C-reactive protein which is an inflammatory marker.
Electronic databases searched for this meta-analysis were Science Direct, Google scholar, Medline and Pubmed from 2003 to June 2016. Thirteen studies were identified for the analysis.4 of these studies involved normal individuals and 9 studies included subjects with the above-mentioned diseases. These studies involved1252 participants who were both healthy individuals as well as subjects with inflammatory diseases. Meta-analysis showed that supplementation of omega-6 doesn't change the level of CRP.(mean difference= -0.169, 95% confidence interval (0.72-1.06), P = 0.71, random-effects model).
This meta-analysis concluded that dietary omega-6 does not increase the risk of inflammation and chronic inflammatory conditions such as diabetes type II and cardiovascular diseases.
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