Systemic lupus erythematosus is a chronic autoimmune disease characterized by the production of auto-antibodies in particular antinuclear antibodies. The association between ANA and the Human leukocyte antigen (HLA) genes in lupus nephritis patients has never been studied on a Moroccan population. The aim of this work was to describe the antinuclear antibodies profile in patients with lupus nephritis and to determine the association between HLA alleles and antinuclear antibodies in lupus nephritis patients. Antinuclear antibodies anti-deoxyribonucleic acid (anti-DNA), anti-histone proteins, anti-nucleosome, anti-SS-A, anti-SS-B, anti-Smith antigen (Sm), anti-RNP (ribonucleoprotein) and anti-ribosomal P-proteins were measured using standard clinical laboratory protocols. HLA typing of class II (DRB1) was tested by ‘‘Polymerase chain reaction sequence specific primers’’ (PCR-SSP) according to micro generic HLA DNA typing trays in 75 patients with LN. DRB1*07 was higher in lupus nephritis patients with anti-SS-A than in those without (p = 0.04). Patients with anti-SS-B had significantly increased frequencies of DRB1*07 versus patients without anti-SS-B.
In the Moroccan population we demonstrated the positive association of HLA-DRB1 with antinuclear antibodies in lupus nephritis patients.
Impact Factor
2022: 6.012
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