Major depressive disorder is a common disorder but is severe and needs attention. Major depressive disorder is episodic and its clinical feature includes loss of social functioning. Social functioning is a broad concept, embracing all human relationships and activities. Social functioning therefore is multidimensional. The present study was designed to assess the social functioning in Patients with Major Depressive Disorder and to examine the Behavioural and Affective factor of Social Functioning. Method: To meet the objectives of the study, Beck’s Depression Inventory and Social Functioning Schedule by Peter Tyrer were used. 30 patients with Major Depressive Disorder were taken as sample from different clinical setup. Result: From the findings, it can be concluded that there is a positive significant relationship between Major Depressive Disorder and Social Functioning; i.e. when depression level goes high, one will have severe difficulties in their social functioning. There were males whose Social Functioning more affected when in Depression.