The present study was designed to determine the effects of lead acetate [Pb(C2H3O2)2] on body weight of mice along with changes in organ weight and malondialdehyde (MDA) levels, a product of cellular lipid peroxidation in tissues. The experiment was carried out on swiss albino mice weighing 20-25g and the mice were divided into three groups. Group I was designated as control whereas group II and group III received lead acetate having doses 10 mg/kg body weight of lead acetate, daily and 150 mg/kg body weight of lead acetate, weekly respectively. Study was performed at 40 and 80 days stages. Mice given lead acetate exposure for 1 day period maintained almost constant body and organ mass whereas daily and weekly doses of lead acetate caused a significant decrease in the average body and organ weight as compared to control. Significantly higher concentration of MDA was measured in tissues which confirm that lipid peroxidation is one of the molecular mechanisms of cell injury in lead acetate poisoning.
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