Autoimmune vesiculobullous lesion of oral cavity and its molecular aspect

One of the remarkable characteristics of the normal immune system is that it is capableof reacting to an enormous variety of microbes, but it does not react against every individual’s own antigens. This unresponsiveness to self -antigens, is also called immunological tolerance. Autoantibodies are directed against various constituents of the molecular apparatus that hold epithelial cells together or that bind the surface epithelium to the underlying connective tissue resulting in Autoimmune Vesiculobullous Disorders. An understanding of the basic molecular aspects of these disorders is essential for proper diagnosis. Once a definitive diagnosis is determined, treatment is focused upon the alleviation of clinical signs and symptoms, referral for consultation with other specialists to assess the extent of the disease process, and the prevention of recurrence.