Backrground: Diabetes is a silent epidemic disease which affects a larger population around the world. It occurs as a result of insulin deficiency or resistance of cells to insulin. India stands seconds in total number of population affected with diabetes following China which is first in position.
Aim: (1) To assess the presence of glucose molecule in saliva similar to that of blood. (2) To estimate the serum and salivary glucose levels by colorimetric method in diabetics and comparing it with healthy subjects.
Study design: A total of 180 subjects were included in the study dividing them into three groups - Normal subjects and diabetic groups were divided into controlled and uncontrolled diabetics based on HbA1Cvalues. (60 subjects in each group).
Materials and Methods: Estimation of serum and salivary glucose was carried out based on GOD-POD principle. The HbA1c values were obtained by WB / Iron – Exchange HPLC method.
Results: Positive correlation between fasting serum glucose and salivary glucose in group I, II and III which was found to be statistically significant (p<0.05). Positive correlation in controlled diabetics(0.2493)and Uncontrolled diabetics (0.3735) was found between post prandial serum glucose and post prandial salivary glucose, which is statistically significant (P<0.05).
Conclusion: Glucose level in saliva and serum of healthy subjects, controlled and uncontrolled diabetics were found to alter according to the serum glucose level. This proves that saliva can be used as a diagnostic tool in monitoring the diabetic status.
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