Hypothyroidism is an endocrinological disease that manifests as varying degrees of thyroid gland failure and metabolic abnormalities. Prominent among them being hypodynamic circulation leading to decreased blood supply to kidneys leading to renal impairment.The present study was undertaken in a tertiary care hospital with the prime objective to evaluate the effect of hypothyroidism on kidney function by assessment of serum uric acid and serum creatinine in primary hypothyroidism patients and by correlating the changes in the levels of these two parameters with serum thyroid hormones.