The most threatening problem of Musi river pollution is from water soluble, non volatile, fairly reactive heavy metals. These exhibit properties of high toxicity, bioaccumulation (or) carcinogenicity when they combines with organic molecules. These have applications as chemical intermediates in the manufacture of pharmaceuticals, chemicals, paints, dyes etc. The discharges from the industrial units engaged in these activities in and around Hyderabad, find their way into Musi river and environment.