Obesity is defined as an excessively high amount of body fat or adipose tissue in relation to lean body mass.Men and women with BMI≥ 30kg/m2 are considered as obese and are generally at higher risk for adverse health events than overweight individuals (BMI= 25.0 – 29.9kg/m2) or lean (BMI Between 18.5 and 24.9 kg/ m2. The objective of the study was to determine the link between central obesity and cardiovascular diseases (CVD) using cardiac markers in the population of Punjab.The present prospective study was undertaken in the Medicine and Biochemistry departments of SGRDIMSAR, Amritsar.Fasting blood samples were drawn from 40 subjectsand sent for biochemical analysis. BMI has a positive and highly significant correlation with waist circumference (WC) at p > 0.01. WC is negatively and significantly correlated with HDL and Nitric Oxide at p > 0.05. A significant correlation is observed betweenCholestrol and Triglycerides p > 0.05 and highly significant correlation is observed between cholesterol, HDL and LDL levels with p > 0.01. Nitric oxide has positive correlation with Lipoprotein and a highly significant correlation with homocysteine at p > 0.01. Myoglobin has a positive correlation with waist circumference at p > 0.05.So the cardiac Markers may prove useful for early identification of susceptible obese individuals who are at high risk of developing CVD.