Background: Interleukin-10 (IL-10) is a pleiotropic cytokine, has both tumor development and tumor suppression properties. The mutation may influence expression of IL-10 gene, resulting in abnormal cell proliferation and development of cancer. Therefore we aim to evaluate the association of IL-10 (-819C/T) gene polymorphism with the risk of OSCC patients in India population.
Methods: A total of 241 OSCC patients and 241 controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism technique for IL-10 (-819C/T).The genotype and allele frequencies of IL-10 (-819C/T) were analyzed by chi-square test and odds ratio (OR) relative risk.
Results: The genotype frequencies of IL-10 (-819C/T) gene polymorphism were significantly increase the risk of OSCC patients (CC vs CT-OR: 0.61; CI: 0.38-0.96; p: 0.044; and CC vs TT-OR: 0.19; CI: 0.090-0.40; p: <0.001).Moreover, the t allele was also associated with increased risk of OSCC (OR: 0.64; CI: 0.50-0.83; p: <0.001). IL-10 (-819C/T) gene polymorphism was not associated with progression of OSCC and environmental risk factor.
Conclusions: The genotype and allele frequencies of IL-10 (-819C/T) gene polymorphism were significantly associated with increased risk of OSCC.
Impact Factor
2022: 6.012
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