To investigate the inhibitory effect of methanol extract of Alpinia galanga root on the growth of calcium hydrogen phosphate dehydrate (CHPD) crystals. CHPD crystals were grown by the single diffusion gel growth technique and the inhibitory effect of methanol extracts of Alpinia galanga root on the growth of CHPD crystals has been studied. The grown crystals were characterized by Fourier Transform Infrared Spectroscopy (FTIR) and Powder X-Ray diffraction (XRD) methods for further confirmations. With an increase in the concentration of methanol extract of Alpinia galanga root, the weight of the formed crystals were gradually reduced from 2.84 g to 0.44 g in CHPD crystals, respectively. The crystals are harvested from the CHPD were characterized by Fourier Transform Infrared Spectroscopy (FTIR) to confirm the functional groups and Powder X-Ray Diffraction technique (XRD) analysis to confirm the crystalline phases of the CHPD crystals. Results obtained are indicated that Alpinia galanga root has the potential to inhibit the formation of CHPD crystals. This study confirms that using methanol extract of Alpinia galanga root can promote the formation of hydroxyapatite (HAP) crystals and reduce the nucleation rate of CHPD crystals, a major component of calcium urinary stone.
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