Considering the world- wide TB issues, there is an earnest need to develop moderately economical new medications to treat this destructive infection. Natural products isolated from plants have assumed a vital part in revelation of medications against irresistible ailments. In the present study, thirty ligand molecules which were present in the plant Acalypha indica were docked with the selected target proteins of Mycobacterium viz. 4RHU, 1W30, 2A7S, 1N2B, 1F0N. Among them Potassium Brevifolincarboxylate had a significant inhibitory activity with 1N2B protein forming bonds at a very low energy value, thus forming a stable complex. The other active compounds were found to be beta-Glucogallin and Caffeic Acid. The active substances from the extracts of Acalypha indica which exhibited promising activities is reported for the first time. These can serve as promising candidates to develop new drugs to combat M. tuberculosis.
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