Orbital cellulitis (OC) is referred to inflammatory process that involves the tissues located posterior to the orbital septum. It reveals with erythema and edema of the eyelids, vision loss, fever, proptosis, chemosis, and diplopia. OC usually develops from sinus infection, infection of the eyelids or face, and even hematogenous spread from distant locations. OC can affect all age groups but is more frequently seen in the pediatric population. Despite of advances in diagnostic and therapeutic options; OC can still lead to serious sight- and life-threatening complications in the modern antibiotics era. Therefore, prompt diagnosis and treatment remain critical. Antibiotic coverage, computed tomography imaging, and surgical intervention have shown promising results and changed the disease prognosis.