Background - Tumor proliferative activity, an important cellular function is closely related to tumor behavior in breast cancer. The objective of this study is to evaluate Ki 67 expression pattern in Triple negative breast cancer patients and correlate with clinicopathological prognostic parameters.
Method – This is a prospective study designed to quantitatively assess the Ki 67proliferative index in retrieved paraffin blocks of fifty triple negative breast cancer patients diagnosed at Department of Pathology, K S Hegde Medical Academy, Deralakatte, Mangalore Karnataka. The Ki 67 expression was correlated with their clinicopathological parameters.
Results - Ki 67 immunoreactivity was highly expressed (> 10% of the tumor cells were positve ) in 29 patients. The Ki 67 proliferation index was significantly associated with high tumor grade (0.000). However, the association with age, tumor size, ductal carcinoma in situ, necrosis, lymphovascular invasion and lymph node metastasis were not statistically significant.
Conclusion- Ki 67 proliferation index is higher in triple negative breast cancer which significantly correlates with tumor grade. Ki 67 proliferation index may be useful in predicting prognosis and management of triple negative breast cancer.
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