Devlopment & evaluation of combination formulation for the immediate delivery of vildagliptin hcl & the sustained delivery of metforminn hcl

Objectives: The present study is concerned with the formulation and evaluation of bilayer tablet with immediate release of Vildagliptin hydrochloride and sustained release of Metformin hydrochloride, used as anti-diabetic drugs in the patients with type-II Diabetes. Experimental Work: In immediate release layer, Crosspovidone was used as fast disintegrating agent and in sustained release layer, fenugreek mucilage (FNM) for bioadhesion sustained release layer .The attempt has been made to combine FNM with well-studied bioadhesive polymers like HPMC K 100M, HPMC K4M and carbopol 934 P. Tablet was prepared by direct compression method. Results: FT-IR studies showed no interaction between drugs and polymers used in the study. Optimized formulation gives release of IR layer in 1 hour (99.35%) and SR layer in 8 hours (83.59%). There is no significance change during stability studies. Conclusion: From the above study we concluded that F8 batch is the best formulation and it give the satisfactory result of immediate release and sustained release of drug from the dosage form. So this formulation is best for the treatment of patient with the type-II diabetes.