Zingiber officinale is ayurvedic medicinal plant known as ginger belongs to family Zingibereceae. From ancient times ginger is consumed as a spice and food additive in the kitchen throughout the world. It has been used as a usual remedy for a range of disease like nausea and vomiting, constipation, fever, jaundice, headache, dementia, pain, arthritis. A long history is available that supports pharmacological role of its compound as anti-cancer, anti-microbial, anti-inflammatory, anti-apoptotic, anti-hyperglycemic, anti-lipidemic, anti-oxidant, anti-diabetic and anti-emetic. This review will assist to expand all information about the earlier period of scientific research and obligatory information about the ginger. It will also explore the medicinal value of ginger in various life-threatening disease. The compounds present in ginger rhizome have major contribution to human health and nutrition. Besides phytochemicals influence on human health, its miRNA might be playing an important role as epigenetic regulator. However, this need to be validated with insilico prediction and real lab experimentation. A lot of study is required to rationale its advantageous use.