Oral cancer and peri implantitis-inflammatory carcinogenesis

Cancer research is a never ending science and shedding light in the pathogenesis and multifactorial causation of cancer is interesting and at occasions puzzling. Chronic inflammation has added a significant dimension in this regard. Biomaterial science has made rapid progression in the recent times and undoubtedly has contributed a great lot in replacement and augmentation. However surprisingly at rare occasions has been a debatable reason for carcinogenesis with chronic inflammation around the implant being the prime cause in evoking transformation of normal cells to neoplastic cells. Inflammation based carcinogenesis results from aberrations in apoptosis and phagocytosis leading to mutations, proliferation and cell damage due to presence of enriched reactive oxygen and nitrogen species leading to cancer prone environment and ultimately biomaterials beyond their benefits thus very rarely lead to inflammation induced oncogenesis.