The rise of chronic health issues world-wide and the increase in health care costs has drawn the interest of researchers for alternatives like agricultural waste which can be utilized for multiple health benefits. Agricultural waste is one of the major sources of pollution if not utilized or discarded properly. These wastes have increased with the growth of food processing industries. Wide variety of fruit and vegetable wastes are disposed-off routinely which if utilized properly may prove to be a boon to human society because of their antimicrobial potential. They can prove to be eco-friendly antimicrobial agents for therapeutic purpose, which may be used for the control of even those microorganisms which have become multidrug resistant on one hand and simultaneous effective disposal of agricultural waste.