Depression disability disorder is a major contributor to the global burden of disease. Today, around 350 million people are estimated to be affected worldwide with this disorder. Depression is different from usual short-lived mood fluctuations. It is a long-lasting mood disorder with moderate to severe intensity and sometimes leads to suicidal incidents. Medically depression is a common but treatable disorder which is difficult to diagnose in the primary stages. A barrier to the effective treatment includes scarcity of appropriate resources, deficit of psychiatrists, misdiagnosis and societal infrastructure. Therefore pertinent resources and trained sensitised physicians are required for proper diagnosis and treatment of depressive disorders. The article reviews the clinical updates for the treatment of depression.