The authors discuss an interesting case of a Pacinian corpuscle neuroma in the palm of a young woman who presented with severe pain. The clinical signs were very subtle.The patient had complete pain relief following excision of the tumour. Pacinian corpuscle neuromas are rare, with only about 70 cases reported in the literature. The histology, presenting featuresand associated conditions are discussed in detail. In addition to a neuroma or glomus tumour, Pacinian corpuscle hyperplasia should be considered in the differential diagnosis of digital or palmar pain of unknown etiology.