Skin cancer is one of the most common form of cancer in developed world. It is known that Ultra Violet radiation or UV is a causative agent of this disease. On the other hand, UV causes skin inflammation almost in a regular manner including sunburn. Chronic inflammation is well known to be associated with cancer promotion and progression. But, the link between the chronic inflammation induced by UV and skin cancer is a field of exploration. This review describes some of the underlying causes of the association between UV induced chronic inflammation and skin cancer.